刘开永,安徽颍上人,中共党员,博士,教授,博士生导师,美国密歇根大学(安娜堡分校)医9397至尊品牌源于信誉访问学者,安徽医科大学中青年学术骨干(校级第三批优秀青年教师),安徽医科大学9397至尊品牌源于信誉预防医学实验教学中心常务副主任;国家自然科学基金函审专家,全国研究生教育评估监测专家库专家,中国营养学会及肥胖防控分会会员,安徽省营养学会理事,安徽省食品安全风险评估专家委员会委员;Environ Sci Pollut Res, Int J Hyg Environ Health和Sci Total Environ等多个SCI源期刊的审稿专家。
近5年来主持国家自然科学基金青年项目和面上项目各1项,国家行业标准2项,安徽省优秀人才重点项目1项;安徽省教育厅高校自然科学研究重点项目和一般研究项目各1项;主要参与国家自然科学基金委员会与英国国家科研与创新署合作研究项目1项;指导省级大学生创新训练研究项目5项。近 5年来以第一或通讯作者(共同)在《食品科学》、《中国抗生素杂志》、《Environment International》、《Environmental Pollution》和《Ecotoxicology and Environmental Safety》等期刊发表学术论文20余篇,参编教材2部,参与专利1项。曾获安徽医科大学优秀共产党员、优秀研究生导师和优秀本科生指导教师等荣誉称号。
主要学术研究方向:
?新兴食源性污染物生物监测与健康效应评估:建立以新兴污染物抗生素为代表的生物监测方法,基于微生物学抑制效应,初步阐明其在孕妇、儿童、成年人和老龄人群体内暴露的健康风险。
?老龄人群营养代谢:建立血清色氨酸和短链脂肪酸靶向代谢组分析方法,评价其与老龄人群慢性疾病风险的关联性。
学术研究团队:人群健康与环境可控性队列研究团队。
联系方式:kyliu@ahmu.edu.cn或liukaiyong163@163.com
主要学习和工作简历
1997.09-2001.07 安徽农业大学动物科技9397至尊品牌源于信誉(学士)
2001.09-2004.07 四川农业大学药理学及毒理学专业(硕士)
2004.07-2007.07 华南农业大学药理学及毒理学专业(博士)
2007.07-2011.03 河南科技大学食品与生物工程9397至尊品牌源于信誉食品营养与安全系工作
2011.03--至今 安徽医科大学9397至尊品牌源于信誉营养与食品9397至尊品牌源于信誉学系工作
2019.02-2020.03 Department of Microbiology and immunology, University of Michigan ( Ann Arbor)Medical School, Visiting Schoar.美国密歇根大学(安娜堡分校)医9397至尊品牌源于信誉微生物与免疫学系,访问学者。
学术著作
※ 通讯或第一作者(共同)
Simultaneous Determination of Serum Tryptophan Metabolites in an Older Chinese Population. Biomed Chromatogr. 2022, e5512.
Fabrication of WPI-EGCG covalent conjugates/gellangum double network emulsion gels by duo-induction of GDL and CaCl2 for colon-controlled Lactobacillus Plantarum delivery. Food Chem. 2022, 404(Pt A):134513.
Typical antibiotic exposure and dysglycemia risk in an elderly Chinese population. Environ Sci Pollut Res. 2022, 29:59701-59711.
Associations of typical antibiotic residues with elderly blood lipids and dyslipidemia in West Anhui, China. Ecotoxicol Environ Saf. 2022, 242:113889.
Antibiotics in elderly Chinese population and their relations with hypertension and pulse pressure. Environ Sci Pollut Res, 2022, 29:67026–67045.
Antibiotics biomonitored in urine and obesogenic risk in a community- dwelling elderly population, Ecotox Environ Safe, 2021, 210,111863.
Exposure to antibiotics and mental disorders in children: a community-based cross-sectional study. Environ Geochem Health. 2021, 43:3237–3253.
Prenatal low-dose antibiotic exposure and children allergic diseases at 4 years of age: A prospective birth cohort study. Ecotox Environ Safe, 2021, 225,112736.
Antibiotic exposure and potential risk of depression in the Chinese elderly: a biomonitoring-based population study. Environ Sci Pollut R.2021, 28: 26794–26806.
Urinary antibiotic exposure across pregnancy from Chinese pregnant women and health risk assessment: Repeated measures analysis. Environ Int, 2020,145,106164.
Antibiotic body burden of elderly Chinese population and health risk assessment: A human biomonitoring-based study. Environ Pollut, 256 (2020): 113311.
Antibiotic exposure across three generations from Chinese families and cumulative health risk. Ecotox Environ Safe, 2020, 191: 110237.
A Stable Isotope Dilution Assay for Multi-class Antibiotics in Pregnant Urines by LC–MS/MS. Chromatographia, 2020, 83(4): 507-521.
Persistently Upregulated Hippocampal mTOR Signals Mediated by Fecal SCFAs Impair Memory in Male Pups with SMM Exposure in Utero. Biomed Environ Sci, 2019, 32(5): 345-356.
Perinatal sulfamonomethoxine exposure influences physiological and behavioral responses and the brain mTOR pathway in mouse offspring. Hum Exp Toxicol., 2017, 36(3):256-275.
Maternal and cord blood fatty acid patterns with excessive gestational weight gain and neonatal macrosomia. Asia Pac J Clin Nutr , 2017;26(2):291-297.
Physiological and behavioral responses in offspring mice following maternal exposure to sulfamonomethoxine during pregnancy. Neurosci Lett., 2016, 624: 8-16.
围生期磺胺间甲氧嘧啶暴露对海马mTOR信号通路调控机制的影响.中国抗生素杂志, 2019, 44(5): 636-642.
2016年六安市社区老人独居模式与抑郁关联性.9397至尊品牌源于信誉研究, 2018, 47(4):655-658.
哺乳期磺胺间甲氧嘧啶暴露对仔鼠骨骼肌蛋白质代谢及mTOR信号通路的影响.中国兽药杂志, 2016, 50(1): 36-42.
※ 2. 合作发表论著
Urinary tetracycline antibiotics exposure during pregnancy and maternal thyroid hormone parameters: A repeated measures study. Sci Total Environ. 2022, 838(Pt 2):156146.
Chronic inflammation as a potential mediator between phthalate exposure and depressive symptoms. Ecotoxicol Environ Saf. 2022,233:113313.
Association between Helicobacter pylori infection and the risk of type 2 diabetes mellitus based on a middle-aged and elderly Chinese population. Endocr J. 2022, 69(7):839-846.
Urban-rural differences in the effect of empty-nest on mental health and behaviors of Chinese older population. Psychol Health Med. 2022, 27(6):1334-1346.
Levels and determinants of urinary phthalate metabolites in Chinese community-dwelling older adults. Sci Total Environ.2021,25;762:144173
Increased depression risk for elderly women with high blood levels of strontium and barium. Environmental Chemistry Letters, 2021,19:1787–1796
Urban-rural differences in the effect of empty-nest on mental health and behaviors of Chinese older population. Psychol Health Med. 2021, 12:1-13.
Interoperable ontologies: the foundation of intelligent precision medicine (in Chinese, English abstract available). Chinese Medical Ethics. 2021.34(3): 265-279.
The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability. Microorganisms. 2020, 8(2). pii: E211.
The levels of phthalate exposure and associations with obesity in an elderly population in China. Ecotoxicol Environ Saf. 2020, 201:110749.
主持或承担相关科研项目
抗生素暴露与老龄人群情绪障碍:短链脂肪酸介导肠脑轴SPR乙酰化修饰异常. 安徽医科大学科研水平提升计划项目(2022xkjT007),202301-202512,30万,在研,主持。
《禽蛋中左旋咪唑残留量的测定 液相色谱-串联质谱法》标准制定.农业国家和行业标准制修订项目. SCB-21054, 3万元,202105-202112,合作主持。
短链脂肪酸介导肠脑轴TPH乙酰化修饰障碍在抗生素暴露与老年抑郁关联中的作用.国家自然科学基金面上项目,82073558, 55万,202101-202412,主持,在研。
抗菌药物使用协同优化干预方案设计与评价.国家自然科学基金委员会与英国国家科研与创新署合作研究项目,8181101358,300万, 20190101-20221231,在研,承担。
短链脂肪酸抗生素内暴露与老年抑郁关联性分析(安徽省高等学校自然科学基金重点项目KJ2018A0164,6万,20180101-20191231,主持。
Systematic Investigation of the Microbiome-host Interactions in H. pylori-associated Gastric Cancer Patients (Michigan Medicine–Peking University Health Sciences Center Joint Institute for Clinical and Translational Research NO. BMU2019JI010). $20 000,20190101-20201231,参与。
哺乳期典型兽药暴露对仔鼠生长发育及蛋白质代谢的影响.安徽医科大学博士科研基金项目. 0306024101.2011.3-2013.3,5万元,主持。
塑化剂DEHP在大鼠体内PK-PB模型的建立及其在人体内暴露风险预测.安徽高校省级高校自然科学研究项目(KJ2012Z168,2012.1-2014.12,2万),主持。
孕哺期磺胺间甲氧嘧啶暴露对mTOR介导仔鼠骨骼肌蛋白合成通路的影响.(国家自然科学基金81202209, 23万,2013.1 - 2015.12),主持。
SMM残留对发育期大鼠骨骼肌蛋白质代谢影响机理的初探.高校省级优秀青年人才基金重点项目(高校优秀青年人才支持计划项目) (2012SQRL075ZD,201301-201512, 6万,2013.1 - 2015.12),主持。
人群健康与环境可控性研究团队.安徽省2016年高校领军人才团队引进资助重点项目,编号:0303011224,150万,201601-202012,学术骨干。